Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.2
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.8
Supplement Facts
Serving Size: 1 Fish Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Cholesterol
<5 mg
1%
Vitamin D3 (as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
Fish Oil Concentrate
1.2 g (1,200 mg)
†
Omega-3 Fatty Acids:
Eicosapentaenoic Acid (EPA)
600 mg
†
Docosahexaenoic Acid (DHA)
300 mg
†
Top Medical Research Studies
9
We delved into the potential of omega-3 polyunsaturated fatty acids, specifically docosahexaenoic acid (DHA), to combat glioblastoma, one of the most aggressive brain tumors.
In our study, we found that DHA treatment led to cell death in glioblastoma cells, as evidenced by signs of apoptosis and increased autophagy. Furthermore, tests in transgenic mice revealed a notable reduction in tumor size and increased activity reflected in cell death markers.
While these findings suggest a promising avenue for GBM treatment, further research is needed to fully understand how omega-3 fatty acids could be integrated into cancer therapies.
In our study, we found that DHA treatment led to cell death in glioblastoma cells, as evidenced by signs of apoptosis and increased autophagy. Furthermore, tests in transgenic mice revealed a notable reduction in tumor size and increased activity reflected in cell death markers.
While these findings suggest a promising avenue for GBM treatment, further research is needed to fully understand how omega-3 fatty acids could be integrated into cancer therapies.
Read More
8
We investigated the potential of docosahexaenoic acid (DHA) liposomes in treating glioblastoma, a challenging type of brain tumor. Using an advanced microfluidic system, we created liposomes that effectively penetrated GBM cells.
The results were promising; the DHA liposomes not only reduced tumor cell viability but also initiated cell death more effectively than regular DHA. This study opens new avenues for cancer treatment using omega-3 fatty acids in liposome formulations, highlighting their potential as a valuable therapeutic strategy.
The results were promising; the DHA liposomes not only reduced tumor cell viability but also initiated cell death more effectively than regular DHA. This study opens new avenues for cancer treatment using omega-3 fatty acids in liposome formulations, highlighting their potential as a valuable therapeutic strategy.
Read More
7
We analyzed data from nine observational studies to better understand the connection between fish consumption and brain tumor risk. Our findings suggest that increasing fish intake may be linked to a 17% lower risk of developing brain cancer, with a notable dose-response relationship.
However, we also emphasize the need for further research, including well-designed cohort studies, to confirm these initial results and clarify any potential confounding factors.
However, we also emphasize the need for further research, including well-designed cohort studies, to confirm these initial results and clarify any potential confounding factors.
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Most Useful Reviews
9
Daily supplement necessity
118 people found this helpful
A basic daily supplement ✔ Capsules contain fish oil as ethyl esters, along with the vital vitamin D3 (1000 IU), crucial for body processes. An excellent composition developed for adults, with two capsules meeting daily requirements. Omega-3 fatty acids concentration is 900mg per capsule: EPA 600mg for heart support, and DHA 300mg for brain function. The fish gelatin capsule has a slight smell, but I easily swallowed it.
Read More
9
Wonderful supplement
1 people found this helpful
Excellent! A wonderful supplement for the brain!
Read More
7.5
Improved brain function
1 people found this helpful
I'm loving this product. After a break, I've resumed taking Omega-3 with this one, rich in EPA/DHA, and I'm quite impressed. My allergies have diminished, brain function is smoother, and I have less belly fat. I don’t want to switch brands anymore.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.2
- All Researches
9
We delved into the potential of omega-3 polyunsaturated fatty acids, specifically docosahexaenoic acid (DHA), to combat glioblastoma, one of the most aggressive brain tumors.
In our study, we found that DHA treatment led to cell death in glioblastoma cells, as evidenced by signs of apoptosis and increased autophagy. Furthermore, tests in transgenic mice revealed a notable reduction in tumor size and increased activity reflected in cell death markers.
While these findings suggest a promising avenue for GBM treatment, further research is needed to fully understand how omega-3 fatty acids could be integrated into cancer therapies.
In our study, we found that DHA treatment led to cell death in glioblastoma cells, as evidenced by signs of apoptosis and increased autophagy. Furthermore, tests in transgenic mice revealed a notable reduction in tumor size and increased activity reflected in cell death markers.
While these findings suggest a promising avenue for GBM treatment, further research is needed to fully understand how omega-3 fatty acids could be integrated into cancer therapies.
Read More
8
We investigated the potential of docosahexaenoic acid (DHA) liposomes in treating glioblastoma, a challenging type of brain tumor. Using an advanced microfluidic system, we created liposomes that effectively penetrated GBM cells.
The results were promising; the DHA liposomes not only reduced tumor cell viability but also initiated cell death more effectively than regular DHA. This study opens new avenues for cancer treatment using omega-3 fatty acids in liposome formulations, highlighting their potential as a valuable therapeutic strategy.
The results were promising; the DHA liposomes not only reduced tumor cell viability but also initiated cell death more effectively than regular DHA. This study opens new avenues for cancer treatment using omega-3 fatty acids in liposome formulations, highlighting their potential as a valuable therapeutic strategy.
Read More
8
We explored the potential of omega-3 fatty acid, docosahexaenoic acid (DHA), to combat glioblastoma, an aggressive brain tumor. By studying patient-derived GBM neural stem-like cells, we found that DHA treatment increases its levels in these cells, assisted by a protein called FABP7. This increase in DHA was linked to a reduction in the cells' ability to migrate, suggesting a possible therapeutic approach to limit tumor spread. However, more research is needed to fully understand the implications of DHA on glioblastoma treatment.
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8
Omega-3 may aid olfactory recovery
We explored how omega-3 fish oil supplementation might support smell recovery in patients after endoscopic brain tumor surgery. In a multicenter trial involving 110 patients, those receiving omega-3 alongside nasal saline experienced less persistent loss of smell compared to peers without it.
Significantly, fewer patients in the omega-3 group reported olfactory issues at three and six months post-surgery. This suggests that omega-3 could play a protective role for the olfactory system during the recovery phase. However, surgery type also influenced outcomes.
Significantly, fewer patients in the omega-3 group reported olfactory issues at three and six months post-surgery. This suggests that omega-3 could play a protective role for the olfactory system during the recovery phase. However, surgery type also influenced outcomes.
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8
Curcumin-DHA shows potential for glioblastoma
We explored a new formulation combining curcumin and docosahexaenoic acid (DHA) for treating brain tumors. By using microemulsions, this treatment showed impressive ability to penetrate the blood-brain barrier.
After administration, the curcumin concentrations in the brain were significantly higher—as much as 66 times greater compared to standard solutions. This suggests the potential of curcumin with DHA for effectively targeting glioblastoma brain cancer. Safety tests indicated that this approach does not harm surrounding tissues, highlighting its promising anticancer effects.
After administration, the curcumin concentrations in the brain were significantly higher—as much as 66 times greater compared to standard solutions. This suggests the potential of curcumin with DHA for effectively targeting glioblastoma brain cancer. Safety tests indicated that this approach does not harm surrounding tissues, highlighting its promising anticancer effects.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Daily supplement necessity
118 people found this helpful
A basic daily supplement ✔ Capsules contain fish oil as ethyl esters, along with the vital vitamin D3 (1000 IU), crucial for body processes. An excellent composition developed for adults, with two capsules meeting daily requirements. Omega-3 fatty acids concentration is 900mg per capsule: EPA 600mg for heart support, and DHA 300mg for brain function. The fish gelatin capsule has a slight smell, but I easily swallowed it.
Read More
9
Wonderful supplement
1 people found this helpful
Excellent! A wonderful supplement for the brain!
Read More
7.5
Improved brain function
1 people found this helpful
I'm loving this product. After a break, I've resumed taking Omega-3 with this one, rich in EPA/DHA, and I'm quite impressed. My allergies have diminished, brain function is smoother, and I have less belly fat. I don’t want to switch brands anymore.
Read More
7.5
Basic product necessity
5 people found this helpful
Best! Great value for money. Advantages of this product include reliability from a trusted company with the highest Omega-3 content among Now Foods products. The quality is exceptional as it uses fish, not cow skin, and heavy metals, particularly mercury, are absent. Even with consumption, there are no side effects! It also contains vitamin D! Omega-3 is proven to improve hair, inflammation, heart health, cholesterol, ageing, and brain function. This is essential as you age!
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9
Improved brain function
1 people found this helpful
This is an excellent supplement with a good composition and noticeable effect. I started taking NOW Foods Ultra Omega-3, 600 EPA/300 DHA for heart health and to improve brain function. Within weeks, I noticed improvements in my energy levels, recovery from workouts, concentration, and memory, positively impacting my work. The supplement also aids in maintaining healthy cholesterol levels. The tablets are large but easy to swallow, with no fishy aftertaste. Highly recommend for heart and brain support.
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Frequently Asked Questions
9
Improved brain function
1 people found this helpful
This is an excellent supplement with a good composition and noticeable effect. I started taking NOW Foods Ultra Omega-3, 600 EPA/300 DHA for heart health and to improve brain function. Within weeks, I noticed improvements in my energy levels, recovery from workouts, concentration, and memory, positively impacting my work. The supplement also aids in maintaining healthy cholesterol levels. The tablets are large but easy to swallow, with no fishy aftertaste. Highly recommend for heart and brain support.
8
Impressive composition
These NOW Foods Ultra-Omega-3 Capsules are a treasure for heart and brain health. After several months of taking them, I've been impressed by the rich composition of EPA and DHA, key for maintaining health. The quality and purity of the fish oil are excellent—I do not experience any unpleasant taste or smell.
6
Reduced forgetfulness
2 people found this helpful
My family takes half the dosage, one pill per day, and we've noticed differences such as no dry eye. We can’t measure improvements in brain function, but age-related forgetfulness is less noticeable. The pill is large, but manageable, with no fishy smell.
7.5
Improved brain function
1 people found this helpful
I'm loving this product. After a break, I've resumed taking Omega-3 with this one, rich in EPA/DHA, and I'm quite impressed. My allergies have diminished, brain function is smoother, and I have less belly fat. I don’t want to switch brands anymore.
7.5
Positive effects noted
My parents have been using NOW Foods Ultra Omega-3 for a while and noticed positive effects. The 600 mg of EPA and 300 mg of DHA per softgel support heart, brain, and joint health, particularly benefiting older adults. They feel more energetic and appreciate the supplement’s quality. Although I don’t take it, they are pleased with the results.
6
Supports cognitive health
176 people found this helpful
This omega contains high levels of EPA and DHA, helping to support the immune, nervous, and cardiovascular systems while activating the brain.
9
Daily supplement necessity
118 people found this helpful
A basic daily supplement ✔ Capsules contain fish oil as ethyl esters, along with the vital vitamin D3 (1000 IU), crucial for body processes. An excellent composition developed for adults, with two capsules meeting daily requirements. Omega-3 fatty acids concentration is 900mg per capsule: EPA 600mg for heart support, and DHA 300mg for brain function. The fish gelatin capsule has a slight smell, but I easily swallowed it.
8
We investigated the potential of docosahexaenoic acid (DHA) liposomes in treating glioblastoma, a challenging type of brain tumor. Using an advanced microfluidic system, we created liposomes that effectively penetrated GBM cells.
The results were promising; the DHA liposomes not only reduced tumor cell viability but also initiated cell death more effectively than regular DHA. This study opens new avenues for cancer treatment using omega-3 fatty acids in liposome formulations, highlighting their potential as a valuable therapeutic strategy.
The results were promising; the DHA liposomes not only reduced tumor cell viability but also initiated cell death more effectively than regular DHA. This study opens new avenues for cancer treatment using omega-3 fatty acids in liposome formulations, highlighting their potential as a valuable therapeutic strategy.
7
We explored the effects of eicosapentaenoic acid (EPA), an omega-3 fatty acid, in conjunction with cisplatin on brain tumor cells. By exposing glioblastoma cells to different treatment combinations, we found that EPA boosted the antitumor effectiveness of cisplatin.
This combination increased oxidative stress and apoptosis by stimulating a specific ion channel (TRPM2) which further promoted calcium entry into the cells. However, while the treatment showed potential in enhancing cancer cell death, the overall benefits need further evaluation to determine if they significantly affect tumor progression or patient outcomes.
This combination increased oxidative stress and apoptosis by stimulating a specific ion channel (TRPM2) which further promoted calcium entry into the cells. However, while the treatment showed potential in enhancing cancer cell death, the overall benefits need further evaluation to determine if they significantly affect tumor progression or patient outcomes.
8
We investigated the impact of omega-3 fatty acids and bioflavonoids in patients undergoing stereotactic radiotherapy for brain metastases. In a study of 405 patients, we found that those who took this supplementation experienced improved survival rates and a reduced risk of radionecrosis, a serious side effect. Our analysis suggested that omega-3s and bioflavonoids could serve as protective agents during treatment, enhancing patient outcomes and safety.
9
We delved into the potential of omega-3 polyunsaturated fatty acids, specifically docosahexaenoic acid (DHA), to combat glioblastoma, one of the most aggressive brain tumors.
In our study, we found that DHA treatment led to cell death in glioblastoma cells, as evidenced by signs of apoptosis and increased autophagy. Furthermore, tests in transgenic mice revealed a notable reduction in tumor size and increased activity reflected in cell death markers.
While these findings suggest a promising avenue for GBM treatment, further research is needed to fully understand how omega-3 fatty acids could be integrated into cancer therapies.
In our study, we found that DHA treatment led to cell death in glioblastoma cells, as evidenced by signs of apoptosis and increased autophagy. Furthermore, tests in transgenic mice revealed a notable reduction in tumor size and increased activity reflected in cell death markers.
While these findings suggest a promising avenue for GBM treatment, further research is needed to fully understand how omega-3 fatty acids could be integrated into cancer therapies.
References
- Mendanha D, Casanova MR, Gimondi S, Ferreira H, Neves NM. Microfluidic-Derived Docosahexaenoic Acid Liposomes for Targeting Glioblastoma and Its Inflammatory Microenvironment. ACS Appl Mater Interfaces. 2024;16:40543. 10.1021/acsami.4c01368
- Mendanha D, Gimondi S, Costa BM, Ferreira H, Neves NM. Microfluidic-derived docosahexaenoic acid liposomes for glioblastoma therapy. Nanomedicine. 2023;53:102704. 10.1016/j.nano.2023.102704
- Öcal Ö, Nazıroğlu M. Eicosapentaenoic acid enhanced apoptotic and oxidant effects of cisplatin via activation of TRPM2 channel in brain tumor cells. Chem Biol Interact. 2022;359:109914. 10.1016/j.cbi.2022.109914
- Choi WS, Xu X, Goruk S, Wang Y, Patel S, et al. FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells. Nutrients. 2021;13. 10.3390/nu13082664
- Yan CH, Rathor A, Krook K, Ma Y, Rotella MR, et al. Effect of Omega-3 Supplementation in Patients With Smell Dysfunction Following Endoscopic Sellar and Parasellar Tumor Resection: A Multicenter Prospective Randomized Controlled Trial. Neurosurgery. 2020;87:E91. 10.1093/neuros/nyz559
- Kim S, Jing K, Shin S, Jeong S, Han SH, et al. ω3-polyunsaturated fatty acids induce cell death through apoptosis and autophagy in glioblastoma cells: In vitro and in vivo. Oncol Rep. 2018;39:239. 10.3892/or.2017.6101
- Shinde RL, Devarajan PV. Docosahexaenoic acid-mediated, targeted and sustained brain delivery of curcumin microemulsion. Drug Deliv. 2017;24:152. 10.1080/10717544.2016.1233593
- Lian W, Wang R, Xing B, Yao Y. Fish intake and the risk of brain tumor: a meta-analysis with systematic review. Nutr J. 2017;16:1. 10.1186/s12937-016-0223-4
- Harvey KA, Xu Z, Saaddatzadeh MR, Wang H, Pollok K, et al. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. 2015;122:547. 10.3171/2014.10.JNS14759
- Wang F, Bhat K, Doucette M, Zhou S, Gu Y, et al. Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis. Curr Mol Med. 2011;11:503.
- Cui PH, Petrovic N, Murray M. The ω-3 epoxide of eicosapentaenoic acid inhibits endothelial cell proliferation by p38 MAP kinase activation and cyclin D1/CDK4 down-regulation. Br J Pharmacol. 2011;162:1143. 10.1111/j.1476-5381.2010.01113.x
- Nasrollahzadeh J, Siassi F, Doosti M, Eshraghian MR, Shokri F, et al. The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression. Lipids Health Dis. 2008;7:45. 10.1186/1476-511X-7-45
- Denkins Y, Kempf D, Ferniz M, Nileshwar S, Marchetti D. Role of omega-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma. J Lipid Res. 2005;46:1278.
- Gramaglia A, Loi GF, Mongioj V, Baronzio GF. Increased survival in brain metastatic patients treated with stereotactic radiotherapy, omega three fatty acids and bioflavonoids. Anticancer Res. 1999;19:5583.
